GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9902453 | 1 | rs4533340 | chr17:28277951 | GIT1 | chr17:27900487-27916610:- | 0.31 | 7.22 | 2.07E-12 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4533340 | chr17:28277951 | LRRC37B2 | chr17:28903483-28992715:+ | 0.18 | 4.03 | 6.62E-5 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4533340 | chr17:28277951 | SSH2 | chr17:27952965-28257018:- | 0.34 | 7.72 | 6.87E-14 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4533340 | chr17:28277951 | TP53I13 | chr17:27895739-27900174:+ | 0.2 | 5.46 | 7.57E-8 | Coffee consumption (cups per day) |
| THCA | cis | rs4534636 | 1 | rs4534636 | chr12:8666801 | CLEC4D | chr12:8666136-8674958:+ | 0.21 | 3.68 | 0.000258 | Response to radiotherapy in prostate cancer (toxicity, urinary frequency) |
| THCA | cis | rs10935120 | 1 | rs4535272 | chr3:134299916 | ANAPC13 | chr3:134196547-134204865:- | -0.39 | -12.53 | 2.41E-31 | Height |
| THCA | cis | rs10935120 | 1 | rs4535272 | chr3:134299916 | CEP63 | chr3:134204575-134293852:+ | -0.3 | -6.48 | 2.33E-10 | Height |
| THCA | cis | rs41997 | 1 | rs4538799 | chr7:118066964 | ANKRD7 | chr7:117864712-117882782:+ | -0.27 | -4.36 | 1.58E-5 | Response to platinum-based chemotherapy in non-small-cell lung cancer |
| THCA | cis | rs4938642 | 1 | rs45439091 | chr11:119054208 | CBL | chr11:119076990-119178858:+ | -0.22 | -4.35 | 1.64E-5 | Platelet count |
| THCA | cis | rs8042680 | 1 | rs4544218 | chr15:91520373 | HDDC3 | chr15:91474157-91475774:- | -0.15 | -3.99 | 7.68E-5 | Type 2 diabetes |
| THCA | cis | rs454422 | 1 | rs454422 | chr20:5943693 | MCM8 | chr20:5931298-5975829:+ | -0.32 | -7.17 | 2.81E-12 | HIV-1 viral setpoint |
| THCA | cis | rs12196860 | 1 | rs4544908 | chr6:55946166 | COL21A1 | chr6:55921389-56258892:- | -0.65 | -8.07 | 5.8E-15 | Psychosis (atypical) |
| THCA | cis | rs12134663 | 1 | rs45449597 | chr1:11857925 | MTHFR | chr1:11845787-11866115:- | 0.23 | 3.45 | 0.000615 | Homocysteine levels |
| THCA | cis | rs2275426 | 1 | rs4545281 | chr1:46360054 | CCDC163P | chr1:45960581-45965646:- | -0.52 | -10.28 | 1.58E-22 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs4545281 | chr1:46360054 | GPBP1L1 | chr1:46092978-46152302:- | 0.16 | 4.06 | 5.76E-5 | Body mass index |